4-Hydroxy-3-methoxy-5-nitrobenzoic acid

Its specific structure allows for further reactions to build Opicapone’s complex oxadiazole ring system, making it a key precursor in creating this important pharmaceutical. 4-Hydroxy-3-methoxy-5-nitrobenzoic acid (also known as 5-nitrovanillic acid) is a crucial intermediate (a building block) in the synthesis of Opicapone, a drug for Parkinson’s disease that inhibits Catechol-O-methyltransferase (COMT) to extend L-Dopa’s effectiveness.

API Name Opicapone
CAS No 15785-54-3
Molecular Formula C8H7NO6
Molecular Weight 213.14 g/mol
Synonyms 4-hydroxy-3-methoxy-5-nitrobenzoic acid