This intermediate is later coupled with another fragment to complete the nintedanib structure. Trimethyl orthobenzoate is employed to synthesize nintedanib in a condensation reaction to form a key intermediate, the benzylidene oxindole derivative.
Trimethyl orthobeznoate
| API Name | Nintedanib |
|---|---|
| CAS No | 707-07-3 |
| Molecular Formula | C10H14O3 |
| Molecular Weight | 182.22 g/mol |
| Synonyms | trimethoxymethylbenzene |
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