It acts by forming active esters with carboxylic acids, which reduces racemization and enhances reaction efficiency when coupled with agents like DCC or EDC. HOBt hydrate is a white to off-white crystalline solid, water-soluble, and improves yields and purity in peptide and ester synthesis reactions. 1-Hydroxybenzotriazole hydrate (HOBt·xH₂O) is a coupling additive widely used in peptide synthesis and amide bond formation.
1-Hydroxybenzotriazole hydrate
| CAS No | 123333-53-9 |
|---|---|
| Molecular Formula | C6H7N3O2 |
| Molecular Weight | 153.14 g/mol |
| Synonyms | 1-hydroxybenzotriazole;hydrate |
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